Highlights in Ubiquinone Research. Am J Clin Nutr 1997;65(2):503-507. Eur J Ophthalmol. Clin Ther. Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. It can help to treat heart failure and other heart conditions, possibly helping to improve some symptoms and lessen future cardiac risks when combined with regular medications. View abstract. Miles, M. V., Tang, P. H., Miles, L., Steele, P. E., Moye, M. J., and Horn, P. S. Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets. View abstract. View abstract. Nahas, R. Complementary and alternative medicine approaches to blood pressure reduction: An evidence-based review. Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. Cochrane.Database.Syst.Rev. View abstract. 2011;111(6):404-405. A surviving case of mitochondrial cardiomyopathy diagnosed from the symptoms of multiple organ dysfunction syndrome. 2015 Feb;238(2):329-35. doi: 10.1016/j.atherosclerosis.2014.12.016. Okuma, K., Furuta, I., and Ota, K. [Protective effect of coenzyme Q10 in cardiotoxicity induced by adriamycin]. Research has found that taking coenzyme Q10 does not lower blood sugar levels in people with type 1 or type 2 diabetes. View abstract. 7-1-2008;47(1):27-30. Tsujita, Y., Kunitomo, T., Fujii, M., Furukawa, S., Otsuki, H., Fujino, K., Hamamoto, T., Tabata, T., Matsumura, K., Sasaki, T., Saotome, T., Kawai, H., Matsumoto, T., Maeda, K., Horie, M., and Eguchi, Y. Coenzyme Q10 (CoQ10) is an essential element that your body produces naturally. View abstract. Research Communications in Chemical Pathology and Pharmacology 1975;12(1):111-124. 2011;11(4):623-625. View abstract. View abstract. Possible anti—aging benefits of taking more CoQ10 include —. Protection by coenzyme Q10 of tissue reperfusion injury during abdominal aortic cross-clamping. However, more clinical trials are still needed to prove these effects. Coenzyme Q10 has been found to prevent lipid peroxidation, which occurs when the cell membranes and LDL are exposed to oxidizing conditions that enter from outside the body. A few rare side effects are mild nausea and loss of appetite, then it is recommended to reduce provisionally the doses of Coenzyme Q10… Taking coenzyme Q10 by, A group of disorders that most often cause muscle weakness (mitochondrial myopathies). View abstract. Clin Nutr. Curr Neurol.Neurosci.Rep. A., and Pons, A. Supplementation with an antioxidant cocktail containing coenzyme Q prevents plasma oxidative damage induced by soccer. Schmitz-Hubsch, T. and Klockgether, T. An update on inherited ataxias. Artuch, R., Brea-Calvo, G., Briones, P., Aracil, A., Galvan, M., Espinos, C., Corral, J., Volpini, V., Ribes, A., Andreu, A. L., Palau, F., Sanchez-Alcazar, J. CNS.Drugs 2009;23(3):213-223. CoQ10 deficiency or lack of CoQ10 is most commonly associated with the damage of free radicals or oxidative stress. Nishino, M., Usami, M., Sugimura, S., and Yoshizaki, S. [Case of drug-induced pneumonitis associated with a dietary supplement containing CoQ10]. Replacement therapy is effective in familial mitochondrial encephalomyopathy with muscle coenzyme Q10 deficiency. 1997;95(1):11-20. View abstract. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Abe, K., Matsuo, Y., Kadekawa, J., Inoue, S., and Yanagihara, T. Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): evaluation by noninvasive tissue oximetry. Decreased level of sperm coenzyme Q10, mitochondrial respiration and energy production in infertile patients therapeutic effect on coenzyme Q10 (a pilot study). Clin Biochem. 1997;41(2):160-165. Lopez, L. C., Schuelke, M., Quinzii, C. M., Kanki, T., Rodenburg, R. J., Naini, A., DiMauro, S., and Hirano, M. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. View abstract. Early Hum.Dev. Suzuki, Y., Kadowaki, H., Atsumi, Y., Hosokawa, K., Katagiri, H., Kadowaki, T., Oka, Y., Uyama, K., Mokubo, A., Asahina, T., and . Stojanovic M, Radenkovic M. A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Robbers JE, Tyler VE. 2007;21(4):297-306. J Altern.Complement Med 2010;16(3):323-325. View abstract. It is not recommended during pregnancy and breast—feeding. A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). 1990;12:155-62. Cochrane Database Syst.Rev. Clinical improvement after administration of coenzyme Q10 in a patient with mitochondrial encephalomyopathy. 2009;19(5):501-506. doi: 10.3390/nu10111697. View abstract. 2014;2014:798957. Chemica Scripta 1987;27:145-153. Roland, L., Gagne, A., Belanger, M. C., Boutet, M., Berthiaume, L., Fraser, W. D., Julien, P., and Bilodeau, J. F. Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia. Zhonghua Nan.Ke.Xue. Kaufmann, P., Thompson, J. L., Levy, G., Buchsbaum, R., Shefner, J., Krivickas, L. S., Katz, J., Rollins, Y., Barohn, R. J., Jackson, C. E., Tiryaki, E., Lomen-Hoerth, C., Armon, C., Tandan, R., Rudnicki, S. A., Rezania, K., Sufit, R., Pestronk, A., Novella, S. P., Heiman-Patterson, T., Kasarskis, E. J., Pioro, E. P., Montes, J., Arbing, R., Vecchio, D., Barsdorf, A., Mitsumoto, H., and Levin, B. Neurology 1994;44(suppl 2):A397-A398. View abstract. Manzoli, U., Rossi, E., Littarru, G. P., Frustaci, A., Lippa, S., Oradei, A., and Aureli, V. Coenzyme Q10 in dilated cardiomyopathy. Dizziness. Swelling (inflammation) of the heart (myocarditis). Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Ugeskr Laeger 1998;160:3226-7. J Neurology 1988;235:S79. Zhang P, Yang C, Guo H, Wang J, Lin S, Li H, et al. In animals, a massive dose of 350mg/kg body weight has been observed to exacerbate the effects of aging, but human studies don't suggest any convincing adverse effects from normal doses. Gastroenterology 1989;97:1033-42. However, not all research has shown benefit. Crane FL. Chest pain (angina). Oxid.Med.Cell Longev. A rare inherited disorder that causes obesity, short stature, and learning disability (Prader-Willi syndrome or PWS). JAMA 2003;289:1681-90. Schiapparelli, P., Allais, G., Castagnoli, Gabellari, I, Rolando, S., Terzi, M. G., and Benedetto, C. Non-pharmacological approach to migraine prophylaxis: part II. View abstract. Schulz, J. Ideggyogy.Sz 1-30-2009;62(1-2):25-34. View abstract. Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants. Nutrients 2018;10(11). Coenzyme Q10 deficiency. Acta Otolaryngol. Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combine dyslipidemia. Bioavailability of two different formulations of coenzyme Q10 in healthy subjects. 2009;15(11):R1-R8. Mortensen, S. A., Vadhanavikit, S., Baandrup, U., and Folkers, K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. View abstract. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. However, it doesn't seem to benefit people with normal coenzyme Q10 levels. Curr Ther Res 1991;49 :878-886. View abstract. View abstract. Cooney, R. V., Dai, Q., Gao, Y. T., Chow, W. H., Franke, A. 2009;66(2):235-244. Lagendijk, J., Ubbink, J. View abstract. As an antioxidant, coenzyme CoQ10 has been used in medical practices for decades, especially for treating cardiovascular diseases. View abstract. Coenzyme Q10 as an immunoenhancer. Muta-Takada, K., Terada, T., Yamanishi, H., Ashida, Y., Inomata, S., Nishiyama, T., and Amano, S. Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells. Am J Cardiol 2007;99:1409-12. B., Delport, R., Vermaak, W. J., and Human, J. Mortensen SA, Vadhanavikit S, Muratsu K, Folkers K. Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. View abstract. J Neurol.Sci. As a precaution, Coenzyme Q10 should be avoided by young children and pregnant women. Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Mild side effects such as insomnia or digestive upsets may occur. Pediatr Cardiol 2005;26:361-6. View abstract. Mol.Genet.Metab 2009;97(4):292-296. Hanioka T, Tanaka M, Ojima M, et al. Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by coenzyme Q. 2012;188(2):526-31. Proc.Natl.Acad.Sci U.S.A 1971;68(10):2332-2335. Rosenfeldt, F. L., Pepe, S., Linnane, A., Nagley, P., Rowland, M., Ou, R., Marasco, S., and Lyon, W. The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. In: Folkers K and Yamamura Y. Biomedical and Clinical Aspects on Coenzyme Q. Amsterdam: Elsevier;1986. First Conference of the International Coenzyme Q10 Association 2002; Weber, C., Bysted, A., and Holmer, G. Coenzyme Q10 in the diet--daily intake and relative bioavailability. Shinyaku to Rinsho 1970;29:1541-1546. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Mischley, L. K., Allen, J., and Bradley, R. Coenzyme Q10 deficiency in patients with Parkinson's disease. Eur.J Neurol. J Thorac.Cardiovasc.Surg. Ramelli, G. P., Gallati, S., Weis, J., Krahenbuhl, S., and Burgunder, J. M. Point mutation tRNA(Ser(UCN)) in a child with hearing loss and myoclonus epilepsy. 2014;71(5):543-52. Some early research shows that taking coenzyme Q10 by mouth might reduce chest pain and improve exercise ability in people with chest pain. Neurology 1998;50:793-5. 2008;22(12):1403-1408. View abstract. There’re some evidence that adding more CoQ10 supplements to your diet may be beneficial. Cardiovascular diseases might occur a migraine preventive mixed results 13-14 ):1174-1176 supplemental ubiquinol in patients congestive... ; 22 ( 5 ):810-812 control of arterial tone after long-term coenzyme Q10 on statin-induced )., diarrhea, … coenzyme Q10, and et al produce ROS and induce damage... ( diabetic nephropathy ) commercial influence with Ginkgo biloba extract in fibromyalgia syndrome, K. clinical experience with idebenone! 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